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PubMed ID:
25884839
Public Release Type:
Journal
Publication Year: 2015
Affiliation: Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland. heikki.hyoty@uta.fi.
DOI:
https://doi.org/10.1186/s12887-015-0333-8
Authors:
Boldison J,
Gallo D,
Davis J,
Pickin RR,
Farber E,
Onengut-Gumuscu S,
Chen WM,
Rich SS,
Jiang N,
Zhao Y,
Nechtman J,
Liu H,
McIndoe R,
She JX,
Ke S,
Higgins H,
Gaur VP,
Marcovina SM,
Petrosino JF,
Wohlgemuth G,
Wong J,
Palazoglu M,
Kind T,
Wikoff B,
Fiehn O,
Fear AL,
Mack SJ,
Erlich H,
Tennill AL,
Little RR,
Lehtonen M,
Leiviskä J,
Sundvall J,
Salminen I,
Erlund I,
Karlsson EL,
Eriksson EA,
Davis B,
Wyatt R,
Ridewood S,
Reed C,
Pearson J,
Payne M,
Long A,
Goode J,
Geoghan I,
Easton P,
Curnock R,
Caygill C,
Carreno G,
Broadhurst J,
Lönnrot M,
Lynch K,
Larsson HE,
Lernmark Å,
Rewers M,
Hagopian W,
She JX,
Simell O,
Ziegler AG,
Akolkar B,
Krischer J,
Hyöty H,
TEDDY Study Group,
Rewers M,
Barriga K,
Bautista K,
Baxter J,
Bedoy R,
Eisenbarth G,
Frank N,
Gesualdo P,
Hoffman M,
Ide L,
Karban R,
Liu E,
Norris J,
Waugh K,
Samper-Imaz A,
Steck A,
Davis B,
She JX,
Schatz D,
Hopkins D,
Steed L,
Thomas J,
Silvis K,
Haller M,
Shankar M,
Sheehan E,
Gardiner M,
McIndoe R,
Liu H,
Nechtman J,
Sharma A,
Williams J,
Foghis G,
Anderson SW,
Ziegler AG,
Beyerlein A,
Bonifacio E,
Hummel M,
Hummel S,
Foterek K,
Kersting M,
Knopff A,
Koletzko S,
Peplow C,
Roth R,
Schenkel J,
Stock J,
Strauss E,
Warncke K,
Winkler C,
Simell OG,
Toppari J,
Hyöty H,
Ilonen J,
Kähönen M,
Knip M,
Koivu A,
Koreasalo M,
Kurppa K,
Lönnrot M,
Mäntymäki E,
Multasuo K,
Mykkänen J,
Näntö-Salonen K,
Niininen T,
Nyblom M,
Rautanen J,
Riikonen A,
Romo M,
Simell A,
Simell B,
Simell S,
Simell T,
Simell V,
Sjöberg M,
Stenius A,
Varjonen E,
Veijola R,
Virtanen SM,
Åkerlund M,
Lernmark Å,
Agardh D,
Andrén-Aronsson C,
Ask M,
Bremer J,
Carlsson UM,
Cilio C,
Ericson-Hallström E,
Fransson L,
Gard T,
Gerardsson J,
Håkansson R,
Hansen M,
Hansson G,
Hyberg S,
Johansen F,
Jonasdottir B,
Jonsson L,
Larsson H,
Lernmark B,
Månsson-Martinez M,
Markan M,
Massadakis T,
Melin J,
Mestan Z,
Rahmati K,
Ramelius A,
Rosenquist A,
Järvirova MS,
Sibthorpe S,
Sjöberg B,
Swartling U,
Trulsson E,
Törn C,
Wallin A,
Wimar Å,
Åberg S,
Hagopian WA,
Yan X,
Killian M,
Crouch CC,
Skidmore J,
Ayres S,
Dunson K,
Heaney D,
Hervey R,
Kindschi R,
Meyer A,
Mulenga D,
Scott E,
Stabbert J,
Williams N,
Willis J,
Becker D,
Franciscus M,
Smith MD,
Daftary A,
Klein MB,
Krischer JP,
Abbondondolo M,
Austin-Gonzalez S,
Brown R,
Burkhardt B,
Butterworth M,
Cuthbertson D,
Eberhard C,
Fiske S,
Gowda V,
Hadley D,
Lee HS,
Liu S,
Liu X,
Lynch K,
Malloy J,
McCarthy C,
McLeod W,
Smith L,
Smith S,
Tamura R,
Uusitalo U,
Vehik K,
Yang J,
Akolkar B,
Bourcier K,
Briese T,
Johnson SB,
Oberste S,
Triplett E,
Yu L,
Miao D,
Bingley P,
Williams A,
Chandler K,
Rokni S,
Butterly J
Studies:
The Environmental Determinants of Diabetes in the Young
Early childhood environmental exposures, possibly infections, may be responsible for triggering islet autoimmunity and progression to type 1 diabetes (T1D). The Environmental Determinants of Diabetes in the Young (TEDDY) follows children with increased HLA-related genetic risk for future T1D. TEDDY asks parents to prospectively record the child's infections using a diary book. The present paper shows how these large amounts of partially structured data were reduced into quantitative data-sets and further categorized into system-specific infectious disease episodes. The numbers and frequencies of acute infections and infectious episodes are shown.
