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PubMed ID:
24034790
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Department of Clinical Sciences, Lund University, Skåne University Hospital SUS, Malmö, Sweden.
DOI:
https://doi.org/10.1111/pedi.12066
Authors:
Rewers M,
TEDDY Study Group,
Haller MJ,
She JX,
Simell O,
Rewers M,
Lernmark Å,
Krischer J,
Hagopian W,
Akolkar B,
Gesualdo P,
Vehik K,
Elding Larsson H,
Ziegler A,
Gallo D,
Davis J,
Pickin RR,
Farber E,
Chen WM,
Rich SS,
Onengut-Gumuscu S,
Jiang N,
Zhao Y,
Nechtman J,
Liu H,
McIndoe R,
Ke S,
Higgins H,
Marcovina SM,
Petrosino JF,
She JX,
Wohlgemuth G,
Wong J,
Palazoglu M,
Kind T,
Wikoff B,
Fiehn O,
Alejandrino M,
Bugawan T,
Erlich H,
Tennill AL,
Little RR,
Lehtonen M,
Leiviskä J,
Sundvall J,
Salminen I,
Erlund I,
Karlsson EL,
Eriksson EA,
Wyatt R,
Ridewood S,
Reed C,
Pearson J,
Goode J,
Geoghan I,
Easton P,
Curnock R,
Carreno G,
Broadhurst J,
Butterly J,
Boldison J,
Long A,
Rokni S,
Chandler K,
Williams A,
Bingley P,
Miao D,
Yu L,
Triplett E,
Oberste S,
Johnson SB,
Briese T,
Bourcier K,
Akolkar B,
Yang J,
Washington E,
Vehik K,
Uusitalo U,
Tamura R,
Smith S,
Smith L,
McLeod W,
McCarthy C,
Malloy J,
Lynch K,
Liu S,
Lee HS,
Hadley D,
Gowda V,
Fiske S,
Eberhard C,
Cuthbertson D,
Butterworth M,
Burkhardt B,
Brown R,
Austin S,
Abbondondolo M,
Krischer JP,
Daftary A,
Dalmagro-Elias M,
Franciscus M,
Becker D,
Williams N,
Stepitova V,
Stabbert J,
Skidmore J,
Scott E,
Mulenga D,
Meyer A,
Marcus P,
Heaney D,
Hammar C,
Franco C,
Fowler G,
Coughlin D,
Bratrude B,
Adams C,
Ayres S,
Hay KM,
Crouch CC,
Killian M,
Yan X,
Hagopian WA,
Åberg S,
Wimar Å,
Wallin A,
Törn C,
Trulsson E,
Swartling U,
Sjöberg B,
Sibthorpe S,
Järvirova MS,
Rahmati K,
Nilsson A,
Månsson-Martinez M,
Melin J,
Massadakis T,
Markan M,
Lernmark B,
Larsson HE,
Karlsson UM,
Jonasdottir B,
Johansen F,
Hyberg S,
Hansen M,
Hansson G,
Gerardsson J,
Gard T,
Fransson L,
Ericson-Hallström E,
Cilio C,
Bremer J,
Ask M,
Andrén-Aronsson C,
Agardh D,
Lernmark Å,
Virtanen SM,
Veijola R,
Varjonen E,
Toppari J,
Stenius A,
Sjöberg M,
Simell V,
Simell T,
Simell B,
Romo M,
Riikonen A,
Nyblom M,
Niininen T,
Nanto-Salonen K,
Mykkänen J,
Mantymaki E,
Lönnrot M,
Knip M,
Ilonen J,
Hyöty H,
Simell OG,
Winkler C,
Warncke K,
Strauss E,
Stock J,
Schenkel J,
Roth R,
Pflüger M,
Peplow C,
Krause S,
Koletzko S,
Knopff A,
Kersting M,
Foterek K,
Hummel S,
Hummel M,
Henneberger L,
Bonifacio E,
Beyerlein A,
Ziegler AG,
Anderson SW,
Foghis G,
Williams J,
Sharma A,
Nechtman J,
Liu H,
McIndoe R,
Gardiner M,
Shankar M,
Haller M,
Silvis K,
Thomas J,
Steed L,
Hopkins D,
Schatz D,
She JX,
Steck A,
Samper-Imaz A,
Waugh K,
Norris J,
Liu E,
Karban R,
Ide L,
Hoffman M,
Gesualdo P,
Frank N,
Eisenbarth G,
Baxter J,
Bautista K,
Barriga K
Studies:
The Environmental Determinants of Diabetes in the Young
The Environmental Determinants of Diabetes in the Young (TEDDY) study is designed to identify environmental exposures triggering islet autoimmunity and type 1 diabetes (T1D) in genetically high-risk children. We describe the first 100 participants diagnosed with T1D, hypothesizing that (i) they are diagnosed at an early stage of disease, (ii) a high proportion are diagnosed by an oral glucose tolerance test (OGTT), and (iii) risk for early T1D is related to country, population, human leukocyte antigen (HLA)-genotypes and immunological markers.
