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Public Release Type:
Journal
Publication Year: 2012
Authors:
Brunt EM,
Kleiner DE,
Wilson L,
Unalp A,
Tonascia J,
Neuschwander-Tetri BA
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
,
The Nonalcoholic Steatohepatitis Research Network (NASH CRN) Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis
The primary response in the Pioglitazone v Vitamin E v Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (PIVENS) trial (NEJM 2010;18:1675) was histologic and defined as decrease in the nonalcoholic fatty liver disease activity score (NAS) =/>2 with at least one point contribution from hepatocellular ballooning and no worsening of fibrosis stage.
