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PubMed ID:
22278338
Public Release Type:
Journal
Publication Year: 2012
Affiliation: Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. jason.cooper@cimr.cam.ac.uk
DOI:
https://doi.org/10.1007/s00125-012-2450-3
Authors:
Smyth D,
Walker NM,
Stevens H,
Yang JH,
She JX,
Eisenbarth GS,
Rewers M,
Todd JA,
Akolkar B,
Concannon P,
Erlich HA,
Julier C,
Morahan G,
Nerup J,
Nierras C,
Pociot F,
Rich SS,
Type 1 Diabetes Genetics Consortium,
Cooper JD,
Howson JM
Studies:
Type 1 Diabetes Genetics Consortium
Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.
