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PubMed ID:
21437871
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA. pramos@wfubmc.edu
DOI:
https://doi.org/10.1002/art.30356
Authors:
Guy RT,
Ziegler JT,
Williams AH,
Ramos PS,
Vyse TJ,
Tsao BP,
Harley JB,
Kimberly RP,
Alarcón-Riquelme ME,
Langefeld CD,
Moser KL,
Vilá LM,
Ramsey-Goldman R,
Jacob CO,
Edberg JC,
Li H,
Lessard CJ,
Comeau ME,
Zidovetzki R,
Criswell LA,
Gaffney PM,
Graham DC,
Graham RR,
Kelly JA,
Kaufman KM,
Brown EE,
Alarcón GS,
Petri MA,
Reveille JD,
McGwin G
Studies:
Inflammatory Bowel Disease Genetics
The overexpression of interferon (IFN)-inducible genes is a prominent feature of systemic lupus erythematosus (SLE); it serves as a marker for active and more severe disease, and is also observed in other autoimmune and inflammatory conditions. This study was undertaken to investigate the genetic variations responsible for sustained activation of IFN-responsive genes in SLE.
