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PubMed ID:
19143813
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. joanna.howson@cimr.cam.ac.uk
DOI:
https://doi.org/10.1111/j.1463-1326.2008.01001.x
Authors:
Todd JA,
Clayton D,
Walker NM,
Howson JM,
Type 1 Diabetes Genetics Consortium
Studies:
Type 1 Diabetes Genetics Consortium
Until recently, human leucocyte antigen (HLA) class II-independent associations with type 1 diabetes (T1D) in the Major Histocompatibility Complex (MHC) region were not adequately characterized owing to insufficient map coverage, inadequate statistical approaches and strong linkage disequilibrium spanning the entire MHC. Here we test for HLA class II-independent associations in the MHC using fine mapping data generated by the Type 1 Diabetes Genetics Consortium (T1DGC).
