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PubMed ID:
19136655
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA. patcon@virginia.edu
DOI:
https://doi.org/10.2337/db08-1551
Authors:
Concannon P,
Nierras C,
Pociot F,
Todd JA,
Hilner JE,
Nerup J,
Rich SS,
Type 1 Diabetes Genetics Consortium,
Chen WM,
Erlich HA,
Julier C,
Morahan G,
Akolkar B
Studies:
Type 1 Diabetes Genetics Consortium
Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk.
