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PubMed ID:
18765632
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Family Investigation of Nephropathy and Diabetes (FIND) Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
DOI:
https://doi.org/10.1167/iovs.07-1633
Authors:
Sartorio V,
Spielman R,
O'Brien SJ,
Chakraborty GM,
Chakraborty R,
Rasooly R,
Kimmel PL,
Briggs JP,
Kessing B,
Hanson R,
Thompson M,
Smith MW,
Winkler C,
Spainhour M,
Young R,
Brooks G,
Viverette S,
Warren S,
Rich SS,
Satko SG,
Horvath A,
Bowden DW,
Freedman BI,
Hernandez L,
Abboud T,
Waseta B,
Sili I,
Sewemaenewa J,
Phillips LM,
Luethe C,
Lovelace R,
Juan R,
Jones L,
Wolford J,
Nelson RG,
Hanson RL,
Knowler WC,
Chester J,
Whitehead T,
Meoni L,
Kao L,
Parekh R,
Klag M,
Ingram-Drake L,
Gonzalez J,
Garcia C,
Chew EY,
Davis MD,
Satko SG,
Bowden DW,
Duggirala R,
Elston RC,
Guo X,
Hanson RL,
Igo RP Jr,
Ipp E,
Kimmel PL,
Knowler WC,
Molineros J,
Nelson RG,
Jun G,
Kramp K,
Quade SR,
Slaughter M,
Zaletel E,
Humbert L,
Getz-Fradley L,
Collins-Schramm HE,
Ipp E,
Li H,
Pahl M,
Seldin MF,
LaPage J,
Walker B,
Arar NH,
Freedman BI,
Adler SG,
Iyengar SK,
Fondran C,
Family Investigation of Nephropathy and Diabetes Research Group,
Abboud HE,
Zager PG,
Saad MF,
Shah VO,
Sedor JR,
Schelling JR,
Scavini M,
Saad MF,
Rotter JI,
Rasooly RS,
Quade SR,
Pahl MV,
Nicholas SB,
Guo X,
Rotter J,
Taylor K,
Budgett M,
Hariri F,
Zager P,
Shah V,
Scavini M,
Bobelu A,
Abboud H,
Arar N,
Duggirala R,
Kasinath BS,
Plaetke R,
Stern M,
Jenkinson C,
Goyes C
Studies:
Family Investigation of Nephropathy and Diabetes
Diabetic retinopathy (DR) and diabetic nephropathy (DN) are serious microvascular complications of diabetes mellitus. Correlations between severity of DR and DN and computed heritability estimates for DR were determined in a large, multiethnic sample of diabetic families. The hypothesis was that (1) the severity of DR correlates with the presence and severity of nephropathy in individuals with diabetes mellitus, and (2) the severity of DR is under significant familial influence in members of multiplex diabetic families.
