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PubMed ID:
18003762
Public Release Type:
Journal
Publication Year: 2008
Affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Rm. 1300, 10900 Euclid Ave., Cleveland, OH 44106-7281, USA.
DOI:
https://doi.org/10.2337/db07-0313
Authors:
Adler SG,
Arar NH,
Bowden DW,
Elston RC,
Freedman BI,
Goddard KA,
Guo X,
Hanson RL,
Ipp E,
Iyengar SK,
Jun G,
Kao WH,
Kasinath BS,
Kimmel PL,
Klag MJ,
Knowler WC,
Nelson RG,
Parekh RS,
Quade SR,
Rich SS,
Saad MF,
Scavini M,
Smith MW,
Taylor K,
Winkler CA,
Zager PG,
Shah VO,
Family Investigation of Nephropathy and Diabetes Research Group,
Schelling JR,
Abboud HE,
Nicholas SB,
Pahl MV,
Sedor JR
Studies:
Family Investigation of Nephropathy and Diabetes
Diabetic nephropathy, the most common cause of end-stage renal disease, aggregates in families and specific ethnic groups. Deconstructing diabetic nephropathy into intermediate, quantitative phenotypes may increase feasibility of detecting susceptibility loci by genetic screens. Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a preliminary whole-genome scan.
