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PubMed ID:
33886506
Public Release Type:
Journal
Publication Year: 2021
DOI:
https://doi.org/10.1172/jci.insight.145514
Authors:
Bhatraju Pavan K., Chai Xin-Ya, Sathe Neha A., Ruzinski John, Siew Edward D., Himmelfarb Jonathan, Hoofnagle Andrew N., Wurfel Mark M., Kestenbaum Bryan R.
Request IDs:
22676
Studies:
Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury
Serum creatinine concentrations (SCrs) are used to determine the presence and severity of acute kidney injury (AKI). SCr is primarily eliminated by glomerular filtration; however, most mechanisms of AKI in critical illness involve kidney proximal tubules, where tubular secretion occurs. Proximal tubular secretory clearance is not currently estimated in the intensive care unit (ICU). Our objective was to estimate the kidney clearance of secretory solutes in critically ill adults.
