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PubMed ID:
34747368
Public Release Type:
Journal
Publication Year: 2021
DOI:
https://doi.org/10.1172/jci.insight.150074
Authors:
Greenbaum Carla J., Serti Elisavet, Lambert Katharina, Weiner Lia J., Kanaparthi Sai, Lord Sandra, Gitelman Stephen E., Wilson Darrell M., Gaglia Jason L., Griffin Kurt J., Russell William E., Raskin Philip, Moran Antoinette, Willi Steven M., Tsalikian Eva, DiMeglio Linda A., Herold Kevan C., Moore Wayne V., Goland Robin, Harris Mark, Craig Maria E., Schatz Desmond A., Baidal David A., Rodriguez Henry, Utzschneider Kristina M., Nel Hendrik J., Soppe Carol L., Boyle Karen D., Cerosaletti Karen, Keyes-Elstein Lynette, Long S. Alice, Thomas Ranjeny, McNamara James G., Buckner Jane H., Sanda Srinath
Request IDs:
22487
,
23199
Studies:
The Effects of Rituximab on the Progression of Type 1 Diabetes in New Onset Subjects
IL-6 receptor (IL-6R) signaling drives development of T cell populations important to type 1 diabetes pathogenesis. We evaluated whether blockade of IL-6R with monoclonal antibody tocilizumab would slow loss of residual β cell function in newly diagnosed type 1 diabetes patients.
