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PubMed ID:
33853887
Public Release Type:
Journal
Publication Year: 2021
DOI:
https://doi.org/10.1681/ASN.2020101399
Authors:
Freedman Barry I., Burke Wylie, Divers Jasmin, Eberhard Lucy, Gadegbeku Crystal A., Gbadegesin Rasheed, Hall Michael E., Jones-Smith Tiffany, Knight Richard, Kopp Jeffrey B., Kovesdy Csaba P., Norris Keith C., Olabisi Opeyemi A., Roberts Glenda V., Sedor John R., Blacksher Erika
Request IDs:
20271
Studies:
African American Study of Kidney Disease and Hypertension Study (Clinical Trial)
Variants in the APOL1 gene are thought to be important contributors to a disparity in the incidence of ESKD among Black people, which is approximately three-fold higher than among White people. No specific treatment or management protocol for APOL1-associated nephropathy currently exists. Using a Delphi consensus process supported by a systematic literature review, a multidisciplinary group agreed on practical measures for care of patients who may have APOL1-associated nephropathy. The recommendations address three areas: (1) counseling, genotyping, and diagnosis; (2) disease awareness and education; and (3) a future vision for the management of patients with APOL1 high-risk genotypes. These recommendations may help clinicians improve awareness and diagnosis of APOL1-associated nephropathy and by doing so, may provide opportunities to reduce health disparities related to kidney disease.
