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PubMed ID:
27274832
Public Release Type:
Journal
Publication Year: 2016
Affiliation: Department of Family Medicine and Public Health , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Family Medicine and Public Health , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Division of Nephrology and Hypertension , Georgetown University Medical Center , Washington, DC , USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA.; Department of Psychiatry , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
DOI:
https://doi.org/10.1093/ckj/sfw010
Authors:
Bhatnagar Vibha, Richard Erin L, Wu Wei, Nievergelt Caroline M, Lipkowitz Michael S, Jeff Janina, Maihofer Adam X, Nigam Sanjay K
Request IDs:
20404
Studies:
Chronic Renal Insufficiency Cohort Study
In the setting of chronic kidney disease (CKD), altered extra-renal urate handling may be necessary to regulate plasma uric acid. The Remote Sensing and Signaling Hypothesis (Nigam S. What do drug transporters really do? Nat Rev Drug Discov 2015; 14: 29-44) suggests that multispecific solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters in different tissues are part of an inter-organ communication system that maintains levels of urate and other metabolites after organ injury.
