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PubMed ID:
33305291
Public Release Type:
Journal
Publication Year: 2020
Affiliation: Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Division of Nephrology, Duke University, Durham, North Carolina.; Division of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota.; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Division of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota.; Renal Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Kansas.; Section of Nephrology, University of Chicago, Chicago, Illinois.; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
DOI:
https://doi.org/10.34067/KID.0001692020
Authors:
Grau Laura, Gitomer Berenice, McNair Bryan, Wolf Myles, Harris Peter, Brosnahan Godela, Torres Vicente, Steinman Theodore, Yu Alan, Chapman Arlene, Chonchol Michel, Nowak Kristen L
Request IDs:
20790
,
20959
Studies:
The HALT Progression of Polycystic Kidney Disease (HALT-PKD)
Higher serum intact fibroblast growth factor 23 (iFGF23) was associated with disease progression in participants with autosomal dominant polycystic kidney disease (ADPKD) in the HALT-PKD Studies. PKD mutation is also an important determinant of progression. We hypothesized that serum levels of iFGF23 and vitamin D metabolites (1,25-dihydroxyvitamin D [1,25(OH)2D] and 25-hydroxyvitamin D [25[OH]D]) differ according to ADPKD mutation and differentially predict clinical end points according to genotype (significant interaction between genotype and mineral metabolites).
