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PubMed ID:
30619992
Public Release Type:
Journal
Publication Year: 2018
DOI:
https://doi.org/10.1002/hep4.1284
Authors:
Sharpton Suzanne R., Yong Germaine J.M., Terrault Norah A., Lynch Susan V.
Request IDs:
21545
Studies:
Longitudinal Assessment of Bariatric Surgery
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism of environmental, dietary, and host‐derived substrates, which produce bioactive metabolites. Perturbations to the composition and associated metabolic output of the gut microbiome have been associated with a number of chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). Here, we review the rapidly evolving suite of next‐generation techniques used for studying gut microbiome composition, functional gene content, and bioactive products and discuss relationships with the pathogenesis of NAFLD.
